Worth Publishing: New York, 2000. Use the link below to share a full-text version of this article with your friends and colleagues. Reductive amination Reaction type Coupling reaction … Reductive amination is an important tool for synthetic organic chemists in the construction of carbon‐nitrogen bonds.  Moreover, compound 58 was found to inhibit α‐fucosidase (Ki = 8.4 µm). A Direct Organocatalytic Entry to Selectively Protected Aldopentoses and Derivatives. Biocatalytic Production of Amino Carbohydrates through Oxidoreductase and Transaminase Cascades. Formal α-Allylation of Primary Amines by a Dearomative, Palladium-Catalyzed Umpolung Allylation of -Substituted 3-Amino-4-halopyridines: A Sequential Boc-Removal/Reductive Amination Mediated by Brønsted and Lewis Acids Reductive amination is an important tool for synthetic organic chemists in the construction of carbon‐nitrogen bonds. For reproduction of material from all other RSC journals. In order to investigated the glycosidase inhibition profiles of the enantiomers of the naturally occurring glycosidase inhibitors (the so‐called “looking glass inhibitors”), Fleet and co‐workers reported a convenient large‐scale synthesis of 1,6‐dideoxygalactostatin 97 (d‐DFJ), the enantiomer of the potent fucosidase inhibitor deoxyfuconojirimycin (l‐DFJ), from the readily available 2,3‐O‐isopropylidene‐d‐gulonolactone, in five steps and 54 % overall yield.36 The straightforward synthesis involved introduction of azide moiety through sulfonylation of the free hydroxy group in compound 93 with trifluoromethanesulfonic anhydride in dichloromethane, followed by nucleophilic displacement of the resulting triflate with sodium azide in DMF to afford the corresponding azidolactone 94 (Scheme 13). The first example of an intramolecular asymmetric reductive amination of a dialkyl ketone with an aliphatic amine has been developed for the synthesis of Suvorexant (MK-4305), a potent dual Orexin antagonist under development for the treatment of sleep disorders.